Epilepsy is a common neurological disorder in which the normal activity of brain cells is sometimes disturbed. This can result in strange sensations, emotions and behaviour. Epilepsy can also cause convulsions, muscle spasms and a loss of consciousness.Around 50 million people have epilepsy worldwide; it is especially prevalent in childhood, adolescence and old age. Epilepsy is the most common serious brain disorder worldwide.
Disease Description:
Normally within our brain, millions of tiny electrical charges are passing between nerve cells and to all parts of the body. Epilepsy interrupts this normal pattern of charges with excessive electric discharges of nerve cells. This can affect a person’s consciousness, movements or sensations for a brief period of time. Epilepsy is a nervous system disorder that causes seizures. Seizures can be caused by head injury, stroke, genital defect, meningitis, aneurysm, withdrawal of alcohol, prescription medicine.Having a single seizure does not necessarily mean that a person has epilepsy. Only when a person has had two or more unprovoked seizures separated by at least 24 hours he or she is considered to have epilepsy.
In order to ease medical communication for treatment purposes but also for clinical trials, it is good to use common international terminology and classification for epilepsy. The International League Against Epilepsy (ILAE) serves the medical community by suggesting formal classifications for epilepsies and seizures.
Etiology:
Epilepsy is classified into three main types (Etiology):
- Idiopathic: where there is no apparent cause, but it is possible that there may be a genetic link
- Symptomatic: where a cause has been found. Causes can include: head injury, brain damage at birth, stroke, brain infection and occasionally brain tumour
- Cryptogenic: where doctors believe there is likely to be a cause but they are unable to find it.
60% of people with epilepsy have idiopathic epilepsy.New terminology and concepts update the classification of 1989 to be consistent with current understanding of the epilepsies in clinical practice. Although the recommended terminology since 2010 for etiology is Genetic, Structural, Metabolic, Immune, Infectious and Unknown, the classification terminology of 1989 is still used in a lot of clinical trials.
Seizure Types:
Following epileptic seizures classification is based on ILAE proposal of 2010:
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Partial (focal, local) seizures
Partial (focal) seizures occur when this electrical activity remains in a limited area of the brain. The person retains awareness or has an altered awareness. The differentiation between simplex and complex partial seizures is not anymore recommended.Partial seizures evolving to secondarily generalised seizures: The seizure starts in one part of the brain but then spreads to both parts. This seizure type was formerly known as secondarily generalised seizure.
Generalised seizures
Generalised seizures (convulsive or non-convulsive) affect both sides of the brainAbsence seizures: They start suddenly and are characterised by staring, loss of expression, unresponsiveness and, stopping any activity they are doing.Myoclonic seizures: A myoclonic seizure is a single or series of jerks (brief muscle contractions). Each jerk is typically milliseconds in duration. Although Myoclonic seizures are classifies ad generalised seizures, for this seizure type the person does not loose consciousness. This seizure type still belongs to generalised seizures as the person is likely to have other seizures (such as tonic clonic seizures) as well as myoclonic seizures.[5]Clonic seizures: A clonic seizure is a seizure involving bilaterally rhythmic jerking. The jerking in a clonic seizure is more sustained and rhythmic than seen in a myoclonic seizureTonic seizures: In a tonic seizure the person’s muscles suddenly become stiff. If they are standing they often fall.Tonic-clonic seizures: An older term for this seizure type is "grand mal." As implied by the name, they combine the characteristics of tonic seizures and clonic seizures.The tonic phase comes first: All the muscles stiffen. Air being forced past the vocal cords causes a cry or groan. The person loses consciousness and falls to the floor. The tongue or cheek may be bitten, so bloody saliva may come from the mouth. After the tonic phase comes the clonic phase: The arms and usually the legs begin to jerk rapidly and rhythmically, bending and relaxing at the elbows, hips, and knees. After a few minutes, the jerking slows and stops. Bladder or bowel control sometimes is lost as the body relaxes. Consciousness returns slowly, and the person may be drowsy, confused, agitated, or depressed.Atonic seizures: In an atonic seizure the person’s muscles suddenly relax and they become floppy
Unclassified epileptic seizures
This is a grouping of seizures that cannot Underline be diagnosed as either a focal or generalised seizure and are thus grouped as unknown.Epileptic spasms: Epileptic spasm consist of a sudden forward flexion of the upper body followed by stiffening.
Further details regarding classification and commonly used diagnostic procedures for epilepsy can be found in the guidance of National Institute for Health and Care Excellence (NICE).